Ulasimang bato as Antihyperurecemic Agent

INVENTORS: NIRPROMP

OVERVIEW: Around 1.6 million Filipinos suffer from gout, which makes it the most common inflammatory type of arthritis in the country. Having hyperuricemia or a high serum uric acid level is directly correlated with the development of gout, renal stones and skin tophi. Approximately 28% of all Filipinos have hyperuricemia. This may be due to a decrease in uric acid excretion because the kidneys are not able to compensate for the high purine load.

TECHNOLOGY FEATURES AND SPECIFICATIONS: Peperomia pellucida is also commonly known as Ulasimang bato or pansit-pansitan. Folklorically, the leaves have been used as a decoction to treat gout, arthritis and urinary tract infections.

Clinical trials involving adults with severe hyperuricemia but were otherwise in good health showed that ulasimang bato decreases the serum uric acid levels within 2 weeks of oral intake. The average drop in uric acid levels reached 78% by 7 weeks of continuous intake, which was similar to the percentage drop in levels after oral intake of allopurinol for the same duration. Joint pains were a common complaint before starting treatment. After 2 weeks of treatment with Ulasimang bato, >85% had satisfactory pain relief. Also, patients treated with Ulasimang bato did not experience “rebound” hyperuricemia, often seen in patients treated with Allopurinol. Physical examination and blood chemistries were normal during the duration that the patients were being treated with ulasimang bato tablet.

The Ulasimang bato tablet is available as a 500 mg of dried and powdered aerial parts.

INDICATIONS: Ulasimang bato is used for the treatment of hyperuricemia and for the relief of gout.  It is prescribed at 80 mg/kg/day in 2 divided doses for the 1st 2 weeks and reduced to 40 mg/kg/day for the next 5 weeks.

MARKET TRENDS AND OPPORTUNITIES: Gout and hyperuricemia is a very common condition in Filipinos. Allopurinol, which is the standard of care in the treatment of hyperuricemia, has several side effects such as Stevens-Johnson syndrome, dizziness and other hypersensitivity reactions. These have not been observed in patients using Ulasimang bato.  Ulasimang bato is well known folklorically for the treatment of gout and arthritis and would readily be accepted by Filipino patients.

CUSTOMER BENEFITS: Ulasimang bato is an affordable, herbal medicine to treat gout and hyperuricemia. It was developed by Filipino researchers from Filipino plants to boost the Philippine Pharmaceutical Industry, provide new cash crops for farmers and offer Filipinos medical and financial benefits.

STATUS: We are in need of pharmaceutical companies willing to produce, manufacture and distribute the product in the Philippine market.